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Invitrogen™ RTN1 Polyclonal Antibody
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Catalog No. PIPA595761
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100 μL
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PIPA595761 100 μL
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Catalog No. PIPA595761 Supplier Invitrogen™ Supplier No. PA595761
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TGVAGVSSAM DHTFSTTSKD GEGSCYTSLI SDICYPPQED STYFTGILQK ENGHVTISES PEELGTPGPS LPDVPGIESR GLFSSDSGIE MTPAESTEVN KILADPLDQM KAEAYKYIDI TRPEEVKHQE QHHPELEDKD LDFKNKDTDI SIKPEGVREP DKPAPVEGKI IKDHLLEEST FAPYIDDLSE EQRRAPQITT PVKITLTEIE PSVETTTQEK TPEKQDICLK PSPDTVPTVT VSEPEDDSPG SITPPSSGTE P; Positive Samples: Mouse lung; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein.

Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
TRUSTED_SUSTAINABILITY

Specifications

Antigen RTN1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.53 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene RTN1
Gene Accession No. Q8K0T0
Gene Alias 0710005K15Rik; 4930441F12Rik; I79_024631; LOC100750648; MGC133250; MGC40985; Neuroendocrine-specific protein; Nsp; R75279; reticulon 1; reticulon-1; RP23-450G14.1; RTN1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
Gene Symbols RTN1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_0669591).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 104001
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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