Invitrogen™ RTN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595761

Catalog No. PIPA595761

Description

Immunogen sequence: TGVAGVSSAM DHTFSTTSKD GEGSCYTSLI SDICYPPQED STYFTGILQK ENGHVTISES PEELGTPGPS LPDVPGIESR GLFSSDSGIE MTPAESTEVN KILADPLDQM KAEAYKYIDI TRPEEVKHQE QHHPELEDKD LDFKNKDTDI SIKPEGVREP DKPAPVEGKI IKDHLLEEST FAPYIDDLSE EQRRAPQITT PVKITLTEIE PSVETTTQEK TPEKQDICLK PSPDTVPTVT VSEPEDDSPG SITPPSSGTE P; Positive Samples: Mouse lung; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein.

Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).

Specifications

• Antigen: RTN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RTN1
• Gene Alias: 0710005K15Rik; 4930441F12Rik; I79_024631; LOC100750648; MGC133250; MGC40985; Neuroendocrine-specific protein; Nsp; R75279; reticulon 1; reticulon-1; RP23-450G14.1; RTN1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 104001
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.53 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8K0T0
• Gene Symbols: RTN1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_0669591).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov