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RUNX1T1 Mouse anti-Human, Clone: OTI1H1, liquid, TrueMAB™
SDP

Catalog No. 501675335
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30 μL
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50-167-5335 30 μL
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Catalog No. 50-167-5335 Supplier OriGene Supplier No. TA504703S
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Description

Mouse Monoclonal Antibody

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 gene fused to the 3′-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 gene fused to the 3′-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Specifications

Antigen RUNX1T1
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI1H1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene RUNX1T1
Gene Accession No. Q06455
Gene Alias AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Gene Symbols RUNX1T1
Host Species Mouse
Immunogen Full length human recombit protein of human RUNX1T1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 30 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 862
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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