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Invitrogen™ RUSC1 Polyclonal Antibody
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Catalog No. PIPA556299
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100 μL
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PIPA556299 100 μL
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Catalog No. PIPA556299 Supplier Invitrogen™ Supplier No. PA556299
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRPSSWLPPT VSVLALVKRG APPEMPSPQE LEASAPRMVQ THRAVRALCD HTAARPDQLS FRRGEVLRVI TTVDEDWLRC G Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.

RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUSC1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RUSC1
Gene Accession No. Q9BVN2
Gene Alias 2210403N08Rik; AA408288; LOC100360417; Nesca; new molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain containing 1; RUN and SH3 domain containing 1-like; RUN and SH3 domain-containing protein 1; RUSC1
Gene Symbols RUSC1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RUSC1. Recombinant protein control fragment (Product #RP-94357).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23623
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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