Invitrogen™ RUSC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556299

Catalog No. PIPA556299

Description

Immunogen sequence: RRPSSWLPPT VSVLALVKRG APPEMPSPQE LEASAPRMVQ THRAVRALCD HTAARPDQLS FRRGEVLRVI TTVDEDWLRC G Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.

RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.

Specifications

• Antigen: RUSC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RUSC1
• Gene Alias: 2210403N08Rik; AA408288; LOC100360417; Nesca; new molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain containing 1; RUN and SH3 domain containing 1-like; RUN and SH3 domain-containing protein 1; RUSC1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23623
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BVN2
• Gene Symbols: RUSC1
• Immunogen: Recombinant protein corresponding to Human RUSC1. Recombinant protein control fragment (Product #RP-94357).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG