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RUVBL2 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI1D9, lyophilized, TrueMAB™
SDP

Catalog No. 501662774
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100 μg
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50-166-2774 100 μg
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Catalog No. 50-166-2774 Supplier OriGene Supplier No. CF504285
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.

Specifications

Antigen RUVBL2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1D9
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene RUVBL2
Gene Accession No. Q9WTM5, Q9Y230
Gene Alias CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B
Gene Symbols RUVBL2
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 113-370 of human RUVBL2 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10856, 20174, 292907, 476418
Target Species Canine, Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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