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Invitrogen™ RUVBL2 Polyclonal Antibody
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Catalog No. PIPA5102515
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100 μL
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PIPA5102515 100 μL
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Catalog No. PIPA5102515 Supplier Invitrogen™ Supplier No. PA5102515
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RUVBL2.

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUVBL2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ruvbl2
Gene Accession No. Q9WTM5, Q9Y230
Gene Alias 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; CGI-46; ECP51; ECP-51; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; INO80J; liebeskummer; lik; mp47; p47; p47 protein; Repressing pontin 52; reptin; Reptin 52; reptin52 protein; RuvB (E coli homolog)-like 2; RuvB like AAA ATPase 2; RuvB like AAA ATPase 2 S homeolog; ruvbl2; RUVBL2 protein; ruvbl2.S; ruvB-like 2; RuvB-like AAA ATPase 2; RuvB-like DNA helicase reptin; RuvB-like protein 2; RVB2; TAP54-beta; TIH2; TIP48; TIP49B; TIP60-associated protein 54-beta; wu:fi25f01; XELAEV_180378471mg; xReptin; zReptin
Gene Symbols Ruvbl2
Host Species Rabbit
Immunogen A synthesized peptide derived from human RUVBL2(Accession Q9Y230), corresponding to amino acid residues M178-P228.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10856, 20174, 292907
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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