Invitrogen™ RUVBL2 Polyclonal Antibody

Catalog No.	Quantity
PIPA578343	100 μL

Catalog No. PIPA578343 Supplier Invitrogen™ Supplier No. PA578343

Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa Predicted Reactivity: Mouse (99%), Rat (99%), Xenopus laevis (88%), Pig (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.

Specifications

• Antigen: RUVBL2
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.29 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene: Ruvbl2
• Gene Accession No.: Q9Y230
• Gene Alias: 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; CGI-46; ECP51; ECP-51; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; INO80J; liebeskummer; lik; mp47; p47; p47 protein; Repressing pontin 52; reptin; Reptin 52; reptin52 protein; RuvB (E coli homolog)-like 2; RuvB like AAA ATPase 2; RuvB like AAA ATPase 2 S homeolog; ruvbl2; RUVBL2 protein; ruvbl2.S; ruvB-like 2; RuvB-like AAA ATPase 2; RuvB-like DNA helicase reptin; RuvB-like protein 2; RVB2; TAP54-beta; TIH2; TIP48; TIP49B; TIP60-associated protein 54-beta; wu:fi25f01; XELAEV_180378471mg; xReptin; zReptin
• Gene Symbols: Ruvbl2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human RUVBL2. The exact sequence is proprietary.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10856
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG