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Tocris Bioscience™ Ruxolitinib
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Catalog No. 706450
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

Ruxolitinib is a potent and selective JAK1/2 inhibitor (IC50 values are 3.3 and 2.8 nM, respectively). Exhibits selectivity for JAK1/2 over Tyk2 and JAK3 (∼6-fold and >130-fold, respectively). Exhibits no significant inhibition against a commercial panel of 26 additional kinases. Inhibits JAK2V617F-mediated signaling and proliferation in Ba/F3 cells and HEL cells. Increases survival rates in a JAK2V617F-driven mouse model. Identified as targeting human host proteins that interact with SARS-CoV-2. Orally bioavailable.

Phosphate salt (Cat. No. 7048) also available.

Specifications

Chemical Name or Material (3 R)-3-Cyclopentyl-3-[4-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 H-pyrazol-1-yl]propanenitrile
CAS 941678-49-5
Quantity 50 mg
Target JAK Kinase Inhibitors
Molecular Formula C17H18N6
Formula Weight 2323
Purity 98%
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