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Tocris™ Ruxolitinib

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

Manufacturer:  Tocris™ 7064/50

Catalog No. 70-645-0

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Ruxolitinib is a potent and selective JAK1/2 inhibitor (IC50 values are 3.3 and 2.8 nM, respectively). Exhibits selectivity for JAK1/2 over Tyk2 and JAK3 (∽6-fold and >130-fold, respectively). Exhibits no significant inhibition against a commercial panel of 26 additional kinases. Inhibits JAK2V617F-mediated signaling and proliferation in Ba/F3 cells and HEL cells. Increases survival rates in a JAK2V617F-driven mouse model. Identified as targeting human host proteins that interact with SARS-CoV-2.Orally bioavailable.

Phosphate salt (Cat. No. 7048) also available.



(3 R)-3-Cyclopentyl-3-[4-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 H-pyrazol-1-yl]propanenitrile
JAK Kinase Inhibitors
50 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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