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Invitrogen™ RWDD3 Polyclonal Antibody
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Catalog No. PIPA520821
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100 μg
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Catalog No. Quantity
PIPA520821 100 μg
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Catalog No. PIPA520821 Supplier Invitrogen™ Supplier No. PA520821
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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse kidney tissue lysate. PA5-20821 can be used with blocking peptide PEP-0935.

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RWDD3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RWDD3
Gene Accession No. P0C7N0, Q8VIL2, Q9Y3V2
Gene Alias 2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Gene Symbols RWDD3
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the amino terminus of human RWDD3.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25950, 65026, 66568
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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