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Invitrogen™ RWDD3 Polyclonal Antibody
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Catalog No. PIPA5114147
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PIPA5114147 100 μL
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Catalog No. PIPA5114147 Supplier Invitrogen™ Supplier No. PA5114147
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ESLLSEPMVH ELVLWIQQNL RHILSQPETG SGSEKCTFST STTMDDGLWI For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 79%; Rat: 86%.

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RWDD3
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene RWDD3
Gene Accession No. Q9Y3V2
Gene Alias 2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Gene Symbols RWDD3
Host Species Rabbit
Immunogen Immunogen sequence: ESLLSEPMVH ELVLWIQQNL RHILSQPETG SGSEKCTFST STTMDDGLWI (aa 92-141).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25950
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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