Invitrogen™ RXRG Monoclonal Antibody (1373)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA14671

Catalog No. MA14671

Description

This antibody is predicted to react with bovine, mouse and non-human primate based on 100% sequence homology. This antibody is specific for the ~48 kDa RXR-gamma protein.

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Specifications

• Antigen: RXRG
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RXRG
• Gene Alias: Nr2b3; Nuclear receptor subfamily 2 group B member 3; retinoic acid receptor RXR-gamma; retinoic X receptor gamma-1; retinoid X receptor; retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma; RXR gamma-1; RXRC; RXRG
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 6258, 83574
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Clone: 1373
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P48443, Q5BJR8
• Gene Symbols: RXRG
• Immunogen: Synthetic peptide corresponding to the hinge region of human RXRG conjugated to KLH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov