RYBP Mouse anti-Canine, Human, Mouse, Clone: OTI2B4, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA504651

Catalog No. 50-167-5297

Description

RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ′Lys-119′, rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ′Lys-119′ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A ′Lys-119′ by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.

Specifications

• Antigen: RYBP
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8CCI5, Q8N488
• Gene Symbols: RYBP
• Immunogen: Full length human recombit protein of human RYBP produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2B4
• Conjugate: Unconjugated
• Gene: RYBP
• Gene Alias: AAP1, APAP-1, DEDAF, YEAF1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23429, 484690, 56353
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid