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RYBP Mouse anti-Canine, Human, Mouse, Clone: OTI2B4, liquid, TrueMAB™ 
Mouse Monoclonal Antibody
Manufacturer: OriGene
TA504651
Description
RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ft.Lys-119 ft., rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ft.Lys-119 ft. on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A ft.Lys-119 ft. by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.Specifications
| RYBP | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q8CCI5, Q8N488 | |
| AAP1, APAP-1, DEDAF, YEAF1 | |
| Mouse | |
| IgG1 | |
| 100 μL | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Primary | |
| 23429, 484690, 56353 |
| Western Blot | |
| OTI2B4 | |
| Unconjugated | |
| RYBP | |
| Liquid | |
| RYBP | |
| Full length human recombit protein of human RYBP produced in E.coli. | |
| Affinity Chromatography | |
| RUO | |
| Antibody | |
| Monoclonal | |
| Canine, Human, Mouse |
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