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RYBP Mouse anti-Human, Clone: OTI7D1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF504653

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ′Lys-119′, rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ′Lys-119′ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A ′Lys-119′ by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.Specifications
RYBP | |
Monoclonal | |
Unconjugated | |
RYBP | |
AAP1, APAP-1, DEDAF, YEAF1 | |
Mouse | |
Affinity Chromatography | |
RUO | |
23429 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI7D1 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q8N488 | |
RYBP | |
Full length human recombit protein of human RYBP produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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