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Tocris Bioscience™ (S)-Crizotinib, >98%

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Quantity:
10 mg
50 mg
Description
Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ∽50% in a colon cancer carcinoma xenograft model.
Specifications
Specifications
Quantity | 10 mg |
Solubility | Soluble to 50mM in DMSO and to 20mM in 1eq. HCl with gentle warming |
Formula Weight | 450.34 |
Purity | >98% |
Molecular Weight (g/mol) | 450.339 |
Chemical Name or Material | 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
Safety and Handling
Recommended Storage | Store at RT |
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