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Invitrogen™ S100A12 Monoclonal Antibody (161205)
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Catalog No. PIMA523925
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100 μg
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Catalog No. Quantity
PIMA523925 100 μg
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Catalog No. PIMA523925 Supplier Invitrogen™ Supplier No. MA523925
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Description

Mouse Monoclonal Antibody

This antibody detects recombinant human EN-RAGE in direct ELISAs. Reconstitute at 0.5 mg/mL in sterile PBS.

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
TRUSTED_SUSTAINABILITY

Specifications

Antigen S100A12
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone 161205
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene S100A12
Gene Accession No. P80511
Gene Alias CAAF1; CAGC; Calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin C; calgranulin-C; CGRP; EN RAGE; ENRAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; MRP6; MRP-6; Neutrophil S100 protein; p6; Protein S100 A12; protein S100-A12; S100 calcium binding protein A12; S100 calcium-binding protein A12; S100 calcium-binding protein A12 (calgranulin C); S100A12
Gene Symbols S100A12
Host Species Mouse
Immunogen E. coli-derived recombinant human EN-RAGE Met1-Glu92.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6283
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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