S100A12 Mouse anti-Human, Clone: OTI1D1, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA502495S
DescriptionS100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of human S100A12 produced in HEK293T cell.|
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