S100A12 Mouse anti-Human, Clone: OTI1D1, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA502495S

Catalog No. 50-167-3548

Description

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.

Specifications

• Antigen: S100A12
• Classification: Monoclonal
• Concentration: 0.68 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P80511
• Gene Symbols: S100A12
• Immunogen: Full length human recombit protein of human S100A12 produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1D1
• Conjugate: Unconjugated
• Gene: S100A12
• Gene Alias: CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6283
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid