Invitrogen™ S100A12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551762

Catalog No. PIPA551762

Description

Immunogen sequence: KLEEHLEGIV NIFHQYSVRK GHFDTLSKGE LKQLLTKELA NTIKNIKDKA VIDEIFQGLD ANQDEQVDFQ EFISLVAIAL KAAHYHTHKE Highest antigen sequence identity to the following orthologs: Mouse - 40%, Rat - 40%.

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.

Specifications

• Antigen: S100A12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: S100A12
• Gene Alias: CAAF1; CAGC; Calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin C; calgranulin-C; CGRP; EN RAGE; ENRAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; MRP6; MRP-6; Neutrophil S100 protein; p6; Protein S100 A12; protein S100-A12; S100 calcium binding protein A12; S100 calcium-binding protein A12; S100 calcium-binding protein A12 (calgranulin C); S100A12
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6283
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P80511
• Gene Symbols: S100A12
• Immunogen: Recombinant protein corresponding to Human S100A12. Recombinant protein control fragment (Product #RP-101906).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG