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Invitrogen™ S1P1 Polyclonal Antibody
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Catalog No. PIPA5120188
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100 μL
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PIPA5120188 100 μL
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Catalog No. PIPA5120188 Supplier Invitrogen™ Supplier No. PA5120188
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Description

Rabbit Polyclonal Antibody

Positive test controls include: NIH/3T3, SH-SY5Y, Mouse kidney. The target is usually found in the following locations: Cell membrane, Endosome, Membrane raft, Multi-pass membrane protein. Immunogen sequence: NSGTNPIIYT LTNKEMRRAF IRIMSCCKCP SGDSAGKFKR PIIAGMEFSR SKSDNSSHPQ KDEGDNPETI MSSGNVNSSS.

S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen S1P1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.62 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene S1PR1
Gene Accession No. O08530, P21453
Gene Alias AI849002; CD antigen CD363; CD363; CD363 antigen; CHEDG1; D1S3362; ECGF1; EDG1; EDG-1; EDG1 (Edg1); Edg1; rhodopsin family G protein-coupled receptor; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; etID43307.22; Lpb1; Lysophospholipid receptor B1; S1p; S1P receptor 1; S1P receptor Edg-1; s1p1; S1PR1; sphingosine 1-phosphate receptor; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor EDG1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1; wu:fb98f05
Gene Symbols S1PR1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 303-382 of human EDG1/HEXIM1 (NP_001391.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13609, 1901
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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