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Invitrogen™ SAA4 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA547606
Description
In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant human Serum Amyloid A4 is observed and less than 1% cross-reactivity with recombinant mouse Serum Amyloid A1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.
Serum Amyloid A4 (SAA4) is a gene that encodes one of the constitutively expressed serum amyloid proteins. Located on chromosome 11, SAA4 is part of the serum amyloid A (SAA) superfamily, which includes other highly homologous genes like SAA1, SAA2, and SAA3. Unlike its counterparts, SAA4 is not an acute-phase reactant but is persistently expressed across different tissues, including plasma, where it associates with high-density lipoprotein (HDL). SAA4 is involved in lipid metabolism and inflammatory responses, albeit not directly induced by inflammatory stimuli like other SAA proteins. It appears as multiple isoforms, some of which may be glycosylated. Recent studies have shown that SAA4 expression encompasses a broad spectrum of physiological conditions and may serve as a marker in diseases involving chronic inflammation and persistent pathological states such as neovascular age-related macular degeneration. The gene's constitutive expression pattern suggests its fundamental role in maintaining homeostasis rather than responding dynamically to acute inflammatory challenges.
Specifications
SAA4 | |
Polyclonal | |
Unconjugated | |
Saa4 | |
amyloid A-5 protein; Constitutively expressed serum amyloid A protein; CSAA; C-SAA; Saa4; Saa-4; Saa5; Saa-5; serum amyloid A 4; serum amyloid A-4 protein; serum amyloid A4, constitutive | |
Goat | |
Antigen affinity chromatography | |
RUO | |
20211 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunoprecipitation, Western Blot | |
0.2 mg/mL | |
PBS with 40% trehalose and No Preservative | |
P31532 | |
Saa4 | |
E. coli-derived recombinant mouse Serum Amyloid A4 Asp19-Phe130. | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG |
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