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Tocris Bioscience™ SAG
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Catalog No. 43661
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1 mg
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43-661 1 mg
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Catalog No. 43-661 Supplier Tocris Bioscience™ Supplier No. 4366/1
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Description

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and nduces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

SAG dihydrochloride (Cat. No. 6390) also available.

Specifications

Quantity 1 mg
Product Type SAG
Purity >99%
Molecular Weight (g/mol) 490.06
Inhibitors SAG

For Research Use Only

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