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R&D Systems™ SAG
SDP

Catalog No. RD10195071 Shop All Novus Products
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Catalog No. Quantity
RD10195071 10 mg
43-661 1 mg
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Catalog No. RD10195071 Supplier R&D Systems™ Supplier No. 4366/10

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Description

A Tocris product, part of R&D Systems. Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and nduces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

SAG dihydrochloride (Cat. No. 6390) also available.

Specifications

Quantity 10 mg
Product Line Tocris
Product Type SAG
Purity >99%
Molecular Weight (g/mol) 490.06
Inhibitors SAG

For Research Use Only

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