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Tocris Bioscience™ SAG dihydrochloride
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Catalog No. 63901RD
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63-901-RD 1 mg
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Catalog No. 63-901-RD Supplier Tocris Bioscience™ Supplier No. 6390/1
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Description

Dihydrochloride salt of SAG; Smo receptor agonist

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

Specifications

Chemical Name or Material 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
CAS 2702366-44-5
Assay Percent Range >99%
Quantity 1 mg
Molecular Formula C28H28ClN3OS.2HCl
Formula Weight Observed MW: 562.98
Purity 98%
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