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R&D Systems™ SALAD1
SDP

Catalog No. RD10188020 Shop All Novus Products
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RD10188020 500 μg
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Catalog No. RD10188020 Supplier R&D Systems™ Supplier No. 8974/500U

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Description

A Tocris product, part of R&D Systems. Ultrabright fluorogenic dye for imaging RNA in living cells; activated by binding Mango aptamers

Key information: SALAD1 is a specific and high-affinity aptamer-ligand for aptamer Mango II (KDapp = 0.69 nM). Green fluorogenic dye displaying 3.5-fold brighter fluorescence than other Mango aptamer dyes such as TO1-biotin. Binds 7.5-fold more tightly to Mango II compared to TO dye. SALAD1 exhibits a binding preference to its target RNA (Mango II) over the other three Mango aptamers (7-, 20- and 16-fold tighter than Mango I, III and IV).

The improved brightness and tighter binding of SALAD1 to Mango aptamers allow detection and tracking of RNA with greater sensitivity and spatial resolution, facilitating studies of RNA localization, dynamics, and expression in live-cell and single-molecule imaging applications.

Used for: imaging RNA in live and fixed cells, even at low concentration.

Application: confocal cellular imaging.

Properties and Photophysical Data: excitation and emission maxima (λ) measured in Mango selection buffer are 511 nm and 540 nm, respectively; quantum yield QY = 0.722; extinction coefficient ε(complex) = 47,284 M-1cm-1; fluorescence enhancement FE = 1,500; fluorescence efficiency E = 2,170 nM-1; brightness = 34,139 M-1cm-1. SALAD1 is cell-permeable.

Specifications

Chemical Name or Material (E)-3-(2-((2-Fluoro-6-(1H-pyrazol-1-yl)benzyl)amino)-2-oxoethyl)-2-((1-methylquinolin-4(1H)-ylidene)methyl)benzo[d]thiazol-3-ium trifluoroacetate
Quantity 500 μg
Product Line Tocris
Target Aptamers
Molecular Formula C30H25FN5OS.C2F3O2
Purity 95%
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