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  5. Tocris Bioscience™ Santacruzamate A

Tocris Bioscience™ Santacruzamate A
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Catalog No. 719150
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71-915-0 50 mg
71-911-0 10 mg
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Catalog No. 71-915-0 Supplier Tocris Bioscience™ Supplier No. 7191/50
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Description

Highly potent and selective HDAC2 inhibitor

Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50 = 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC50 = 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50 >1 μM for HDAC4). Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line. Identified as targeting human host proteins that interact with SARS-CoV-2.

Specifications

Chemical Name or Material Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
CAS 1477949-42-0
Quantity 50 mg
Target Class II Histone Deacetylases Inhibitors
Molecular Formula C15H22N2O3
Purity 0.98
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