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Tocris Bioscience™ SAR 7334
GREENER_CHOICE

Catalog No. 58315
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5mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent TRPC6 inhibitor

SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

Specifications

Chemical Name or Material 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
CAS 1333207-63-8
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C21H22ClN3O.2HCl
Formula Weight Observed MW: 440.79
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