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Tocris Bioscience™ Saracatinib
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Catalog No. 718950
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71-895-0 50 mg
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Catalog No. 71-895-0 Supplier Tocris Bioscience™ Supplier No. 7189/50
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Description

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Saracatinib is a potent and selective Src tyrosine kinase family inhibitor (IC50 = 4-10 nM). Inhibits Src, c-Yes, Fyn, Lyn, Blk, Fgr, and Lck. Exhibits selectivity over other tyrosine kinases (IC50 values are 30, 66 and 200 nM for v-Abl, EGFR and c-Kit, respectively). Suppresses invasion of HT1080 cells through a collagen matrix and inhibits metastasis in a murine model of bladder cancer. Inhibits the growth of prostate cancer cell lines. Also suppresses MERS-CoV replication at the early stage of replication (EC50 = 2.9 μM) and displays broad-spectrum activity against other human coronaviruses. Also blocks dengue virus RNA replication. Reverses memory deficit in a mouse AD model and rescues synapse density. Inhibits osteoclast activity, resorption and formation. Induces autophagy. Orally bioavailable.

Specifications

Chemical Name or Material N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2 H-pyran-4-yl)oxy]-4-quinazolinamine
CAS 379231-04-6
Quantity 50 mg
Target Src Family Kinase Inhibitors
Molecular Formula C27H32ClN5O5
Purity 0.98
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