Invitrogen™ SARM Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120750

Catalog No. PIPA5120750

Description

Positive test controls include: 293T, SH-SY5Y. Immunogen sequence: ALDKCMQDHD CKDWVHKEIV TALSCGKNIV PIIDGFEWPE PQVLPEDMQA VLTFNGIKWS HEYQEATIEK IIRFLQGRSS RDSSAGSDTS LEGAAPMGPT.

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). [UniProt].

Specifications

• Antigen: SARM
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SARM1
• Gene Alias: A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23098
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 2.09 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q6SZW1
• Gene Symbols: SARM1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG