Invitrogen™ SARS-CoV-2 Nucleocapsid Monoclonal Antibody (3868)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA547528

Catalog No. PIMA547528

Description

Specificity: Specific for the nucleocapsid of Covid-19 virus. Cross reacts with SARS. Non-reactive with: Influenza A, Influenza B, Adenovirus & MERS. Reactive with the nucleocapsids of Variants: UK B.1.1.7, SA B.1.351, Brazil P.1, B.1.617.2 (Delta), B.1.1.529 (Omicron) & BA.7. Purified preparations consist of >90% pure mouse monoclonal antibody which has been purified from ascites fluid by protein A chromatography. The final preparation is formulated to a protein concentration of 100 μg/mL in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Each vial contains 1.0 mL. This product contains no stabilizing proteins and should be stored at 4C until ready for use. Working dilution must be determined by the user. Suggested starting ranges are 1:10-1:50 for ICC/IF and 1:20-1:200. for ELISA.

SARS-CoV-2 Nucleocapsid Protein is associated with nucleic acid. It is the most abundant protein for coronavirus. Because of the strong immunogenicity of coronavirus Nucleocapsid, it is believed that SARS-CoV-2 Nucleocapsid Protein has potential value for the diagnosis of the virus. The SARS-CoV-2 N protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that involve this process are poorly understood. N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs. The two folded domains interact minimally such that full-length N protein is a flexible and multivalent RNA-binding protein. SARS-CoV-2 causes illnesses ranging from the common cold to severe diseases.

Specifications

• Antigen: SARS-CoV-2 Nucleocapsid
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.2
• Gene Accession No.: P0DTC9
• Gene Symbols: N
• Immunogen: Proprietary sequence.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunocytochemistry
• Clone: 3868
• Conjugate: Unconjugated
• Gene: N
• Gene Alias: COVID19 Nucleocapsid; COVID-19 nucleocapsid; COVID19 Spike nucleocapsid; SARS-CoV-2 N
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 43740575
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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