Invitrogen™ SARS-CoV-2 ORF7b Recombinant Rabbit Monoclonal Antibody (HL1453)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA547052

Catalog No. PIMA547052

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial.

The accessory proteins of coronaviruses are essential for virus-host interactions and the modulation of host immune responses It has been reported that accessory protein ORF3a encoded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can induce apoptosis, and accessory protein ORF6 and ORF8 could be inhibitors of the type-I interferon (IFN) signaling pathway However, the function of accessory protein ORF7b is largely unknown Recent studies have shown that ORF7b promoted expression of IFN-beta, TNF-alpha, and IL-6, activated type-I IFN signaling through IRF3 phosphorylation, and activated TNF alpha-induced apoptosis in HEK293T cells and Vero E6 cells [PMID: 34484133].

Specifications

• Antigen: SARS-CoV-2 ORF7b
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: HL1453
• Conjugate: Unconjugated
• Gene Alias: COVID19 ORF7b
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of SARS-CoV-2 (COVID-19) ORF7b. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

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