SARS-CoV-2 Spike Protein (RBD) Recombinant Human Monoclonal Antibody (T01KHu), Invitrogen™

Human Recombinant Monoclonal Antibody

Supplier:  Invitrogen 703958

Catalog No. 70-395-8

Description

This antibody recognizes the RBD domain of SARS CoV2 Spike protein. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. This antibody is not recommended for the Western blot application.

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.

Specifications

• Antigen: SARS-CoV-2 Spike Protein (RBD)
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Host Species: Human
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Luminex, Neutralization
• Clone: T01KHu
• Conjugate: Unconjugated
• Gene Alias: Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2
• Immunogen: This antibody was developed using computationally derived variants of SARS-CoV antibody structures and is shown to bind Spike Protein S1 subunit (RBD) of SARS CoV2
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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