Invitrogen™ SARS-CoV-2 Spike Protein S1 (B.1.617.2) His-Avi Tag Recombinant Protein, Biotin

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. The mutations were identified in the SARS-CoV-2 varient known as B.1.617.2

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. SARS-CoV-2 Spike Protein is composed of S1 domain and S2 domain (Spike Protein). The Spike protein is the main surface antigen of the coronavirus. The glycosylated Spike protein (as well as the nucleocapsid protein) can be detected in infected cell culture supernatants with antisera from SARS patients. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. CoV diversity is reflected in the variable Spike proteins (S proteins), which have evolved into forms differing in their receptor interactions and their response to various environmental triggers of virus-cell membrane fusion.

Specifications

• For Use With (Application): Control
• Format: Lyophilized
• Formulation: PBS with 0.01% mannitol, 0.01% Tween 80, 5-8% trehalose and no preservative; pH 7.4
• Molecular Weight (g/mol): 85.61 kDa
• Name: SARS-CoV-2 Spike Protein S1 (B0.1.617.2) His-Avi Tag
• Purification Method: SDS-PAGE
• Quantity: 20 μg
• Regulatory Status: RUO
• Endotoxin Concentration: <1.0 EU/μg
• Gene Alias: Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2
• Common Name: SARS-CoV-2 Spike Protein S1
• Product Type: Protein
• Conjugate: Biotin
• Recombinant: Recombinant
• Protein Tag: His-tag, Avi-tag
• Sequence: SARS-CoV-2 spike S1 (Accession # YP_009724390.1), amino acids Met1-Arg685 with a (157-158) deletion and T19R, G142D, E156G, L452R, T478K, D614G, P681R substitutions and a C-terminal His-tag and Avi-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: >95% as determined by SDS-PAGE.