Invitrogen™ SASS6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531301

Catalog No. PIPA531301

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Human (99%), Mouse (88%), Rat (92%), Chicken (83%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: SASS6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SASS6
• Gene Alias: 2810453L12Rik; HsSAS-6; MCPH14; RGD1306255; SAS6; SAS-6; SAS-6 centriolar assembly protein; Sass6; spindle assembly 6 homolog; spindle assembly 6 homolog (C. elegans); spindle assembly abnormal protein 6 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 163786
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q6UVJ0
• Gene Symbols: SASS6
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 160 of Human SASS6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG