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Invitrogen™ SATB1 Polyclonal Antibody
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Catalog No. PIPA5119646
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100 μL
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PIPA5119646 100 μL
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Catalog No. PIPA5119646 Supplier Invitrogen™ Supplier No. PA5119646
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Description

Rabbit Polyclonal Antibody

Positive Control: Mouse thymus tissue lysate,SH-SY-5Y, Jurkat. Subcellular Location: Nucleus.

SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling. SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SATB1
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Satb1
Gene Accession No. Q01826, Q60611
Gene Alias 2610306G12Rik; AW413156; DNA-binding protein SATB1; SATB homeobox 1; Satb1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); special AT-rich sequence-binding protein 1
Gene Symbols Satb1
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal human SATB1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20230, 6304
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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