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Invitrogen™ SATB2 Monoclonal Antibody (CL0323)
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Catalog No. PIMA534977
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100 μL
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Catalog No. Quantity
PIMA534977 100 μL
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Catalog No. PIMA534977 Supplier Invitrogen™ Supplier No. MA534977
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Description

Mouse Monoclonal Antibody

Immunogen sequence: KECPLSQSMI SSIVNSTYYA NVSATKCQEF GRWYKKYKKI KVERVERENL SDYCVLGQRP MHLPNMNQLA SLGKTNEQSP HSQIHHSTPI RNQVPALQPI MSPGLLSPQL SPQLV Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SATB2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL0323
Concentration 1.00 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SATB2
Gene Accession No. Q9UPW6
Gene Alias DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
Gene Symbols SATB2
Host Species Mouse
Immunogen Recombinant protein fragment of Human SATB2 (Product #RP-93679)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23314
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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