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SATB2 Mouse anti-Human, Clone: OTI7E11, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA800843

Encompass_Preferred

Catalog No. 50-167-8588


May include imposed supplier surcharges.
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Description

Description

Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.
Specifications

Specifications

SATB2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9UPW6
SATB2
Human recombit protein fragment corresponding to amino acids 447-733 of human SATB2 produced in E.coli.
100 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
OTI7E11
Unconjugated
SATB2
GLSS
Mouse
Affinity Chromatography
RUO
23314
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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