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SATB2 Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993513
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50-199-3513 10 μL
50-199-3512 100 μL
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Catalog No. 50-199-3513 Supplier Active Motif Supplier No. 61576
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Description

Rabbit Polyclonal Antibody

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

Specifications

Antigen SATB2
Applications Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene SATB2
Gene Accession No. Q9UPW6
Gene Alias DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; Kiaa1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; Special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
Gene Symbols SATB2
Host Species Rabbit
Immunogen This antibody was raised against a peptide within the C-terminal region of human SATB2.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23314
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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