Invitrogen™ SATB2 Recombinant Rabbit Monoclonal Antibody (PD01-42)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA550745

Catalog No. FEMA550745

Description

Positive control: Human colon tissue, human colon carcinoma tissue, human appendix tissue. Predicted band size: 82.5 kDa Subcellular Location: Nucleus.

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

Specifications

• Antigen: SATB2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9UPW6
• Gene Symbols: SATB2
• Immunogen: Synthetic peptide within C terminal human SATB2 aa 680-733/733.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Clone: PD01-42
• Conjugate: Unconjugated
• Gene: SATB2
• Gene Alias: DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23314
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid