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SAV1 Mouse anti-Human, Clone: OTI7C7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF804928

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.Specifications
SAV1 | |
Monoclonal | |
Unconjugated | |
SAV1 | |
SAV, WW45, WWP4 | |
Mouse | |
Affinity Chromatography | |
RUO | |
60485 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI7C7 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9H4B6 | |
SAV1 | |
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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