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SAV1 Mouse anti-Human, Clone: OTI7C7, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF804928

Encompass_Preferred

Catalog No. 50-166-7218


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Specifications

Specifications

SAV1
Monoclonal
Unconjugated
SAV1
SAV, WW45, WWP4
Mouse
Affinity Chromatography
RUO
60485
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI7C7
PBS with 8% trehalose and no preservative; pH 7.3
Q9H4B6
SAV1
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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