Invitrogen™ SAV1 Polyclonal Antibody

Catalog No.	Quantity
PIPA597317	100 μL

Catalog No. PIPA597317 Supplier Invitrogen™ Supplier No. PA597317

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LPLPPGWSVD WTMRGRKYYI DHNTNTTHWS HPLEREGLPP GWERVESSEF GTYYVDHTNK KAQYRHPCAP SVPRYDQPPP VTYQPQQTER NQSLLVPANP YHTAEIPDWL QVYARAPVKY DHILKWELFQ LADLDTYQGM LKLLFMKELE QIVKMYEAYR QALLTELENR KQRQQWYAQQ HGKNF Positive Samples: HeLa, SKOV3, SW480; Cellular Location: Cytoplasm, Nucleus.

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Specifications

• Antigen: SAV1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.87 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene: SAV1
• Gene Accession No.: Q8VEB2, Q9H4B6
• Gene Alias: 1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
• Gene Symbols: SAV1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 199-383 of human SAV1 (NP_0685901).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 60485, 64010
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG