Invitrogen™ SAV1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551639

Catalog No. PIPA551639

Description

Immunogen sequence: IGRVAATSLG NLTNHGSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG WERVESSEFG TYYVDHTNKK AQYRHPCAPS VPRYDQPPPV TYQPQQTERN QSLLVPANPY HTAEIPDWLQ VYARAPVKYD HILKWELFQL A Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Specifications

• Antigen: SAV1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SAV1
• Gene Alias: 1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 60485
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H4B6
• Gene Symbols: SAV1
• Immunogen: Recombinant protein corresponding to Human SAV1. Recombinant protein control fragment (Product #RP-88873).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov