Invitrogen™ SAV1 Recombinant Rabbit Monoclonal Antibody (6H5L16)

Catalog No.	Quantity
70-300-2	100 μg

Catalog No. 70-300-2 Supplier Invitrogen™ Supplier No. 703002

Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicting to react with Monkey, Cat, Dog. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Specifications

• Antigen: SAV1
• Applications: Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 6H5L16
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: SAV1
• Gene Accession No.: Q9H4B6
• Gene Alias: 1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4
• Gene Symbols: SAV1
• Host Species: Rabbit
• Immunogen: Protein corresponding to human SAV1 [aa300-aa383].
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 60485
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov