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  8. SB 203580, Tocris Bioscience™ 

SB 203580, Tocris Bioscience™
GSA_VAGREENER_CHOICE

Catalog No. 120250
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Quantity:
1 mg
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of p38 MAPK

SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.

Water-soluble Salt also available.

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Chemical Identifiers

CAS 152121-47-6
Molecular Formula C21H16FN3OS
Molecular Weight (g/mol) 377.437
InChI Key CDMGBJANTYXAIV-UHFFFAOYSA-N
Synonym 4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl
PubChem CID 176155
IUPAC Name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

Specifications

Quantity 50 mg
Formula Weight 377.44
Percent Purity >98%
Chemical Name or Material SB 203580

Safety and Handling

Recommended Storage Store at +4°C
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