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Tocris Bioscience™ SB 203580
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Quantity:
1 mg
10 mg
50 mg
Description
SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.
Water-soluble Salt also available.
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Specifications
Specifications
| Quantity | 50 mg |
| Formula Weight | 377.44 |
| Purity | >98% |
| Molecular Weight (g/mol) | 377.437 |
| Chemical Name or Material | SB 203580 |
Safety and Handling
| Recommended Storage | Store at +4°C |
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