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R&D Systems™ SB 24011
SDP

Catalog No. 80105 Shop All Novus Products
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5 mg
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Catalog No. Quantity
80-105 5 mg
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Catalog No. 80-105 Supplier R&D Systems™ Supplier No. 8010/5

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Description

A Tocris product, part of R&D Systems. Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP .

Specifications

Chemical Name or Material 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
CAS 1497415-41-4
Quantity 5 mg
Product Line Tocris
Target Protein Dimerizers
Molecular Formula C34H38N4O7
Physical Form Solid
Color Orange
Product Type Bioactive Small Molecule
Purity 0.98
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