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Invitrogen™ SBP2 Polyclonal Antibody
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Catalog No. PIPA5106338
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PIPA5106338 100 μL
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Catalog No. PIPA5106338 Supplier Invitrogen™ Supplier No. PA5106338
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SECISBP2.

Eukaryotes require a selenocysteine (Sec) insertion sequence (SECIS) element in the 3' untranslated region of the mRNA to decode the UGA codon as Sec. SECIS-binding protein 2 (SBP-2) specifically binds selenoprotein mRNAs to form a functional complex and is essential for the insertion of Sec into selenoproteins. Purified SBP-2 interacts specifically with the SECIS element in the phospholipid hydroperoxide glutathione peroxidase mRNA. SBP-2 shows binding activity in the liver and testis as well as hepatoma cells. SBP-2 binds to a conserved RNA binding domain shared with several ribosomal proteins and eukaryotic translation termination release factor 1. A second domain located N-terminal to the RNA binding domain required for Sec insertion allows SBP-2 to stably associate with the ribosomal fraction of cells. SBP-2 preferentially stimulates incorporation directed by the selenoprotein P and phospholipid hydroperoxide glutathione peroxidase SECIS elements. SBP-2 may have a distinct function in selecting the ribosomes for Sec insertion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SBP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SECISBP2
Gene Accession No. Q96T21, Q9QX72
Gene Alias 2210413N07Rik; 2810012K13Rik; DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11-89K14.1; Sbp2; SECIS binding protein 2; SECIS-binding protein 2; SECISBP2; Selenocysteine insertion sequence-binding protein 2
Gene Symbols SECISBP2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SECISBP2(Accession Q96T21), corresponding to amino acid residues V680-N730.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 75420, 79048, 79049
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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