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Tocris Bioscience™ SC 144 hydrochloride Available on GSA/VA Contract for Federal Government customers only.

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Manufacturer:  Tocris Bioscience™ 4963/10

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Catalog No. 49-631-0


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Description

Description

Inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

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