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Tocris Bioscience™ SC 144 hydrochloride
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Catalog No. 496310
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10 mg
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Catalog No. Quantity
49-631-0 10 mg
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Catalog No. 49-631-0 Supplier Tocris Bioscience™ Supplier No. 4963/10
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Description

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

SC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Specifications

Quantity 10 mg
Product Type SC 144 hydrochloride
Purity >99%
Molecular Weight (g/mol) 358.76
Inhibitors SC 144 hydrochloride

For Research Use Only

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