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SC 514, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.
Specifications
Quantity | 10 mg |
Formula Weight | 224.3 |
Percent Purity | >98% |
Chemical Name or Material | SC 514 |
Safety and Handling
Recommended Storage | Store at +4°C |
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