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Invitrogen™ SCF Monoclonal Antibody (13302)
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Catalog No. PIMA523705
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500 μg
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Catalog No. Quantity
PIMA523705 500 μg
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Catalog No. PIMA523705 Supplier Invitrogen™ Supplier No. MA523705
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Description

Mouse Monoclonal Antibody

This antibody detects recombinant human SCF in Western blots. In sandwich ELISAs, no significant cross-reactivity or interference was observed with 36 other cytokines. Reconstitute at 0.5 mg/mL in sterile PBS.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCF
Applications ELISA, Western Blot
Classification Monoclonal
Clone 13302
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene KITLG
Gene Accession No. P21583
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Gene Symbols KITLG
Host Species Mouse
Immunogen E. coli-derived recombinant human SCF Glu26-Ala189.
Purification Method Protein A/G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4254
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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