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Invitrogen™ SCF Polyclonal Antibody
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Catalog No. PIPA519793
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100 μg
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PIPA519793 100 μg
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Catalog No. PIPA519793 Supplier Invitrogen™ Supplier No. PA519793
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Description

Rabbit Polyclonal Antibody

For Western Blot, this antibody has non-specific bands at 120 kDa and 50 kDa. Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with rat, sheep, goat, horse, cow, cat, dog, pig and rhesus monkey based on sequence homology.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCF
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene KITLG
Gene Accession No. P21583
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Gene Symbols KITLG
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human SCF.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4254
Target Species Human, Monkey
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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