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SCF Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS0545R

Encompass_Preferred

Catalog No. 50-198-0346


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Description

Description

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Specifications

Specifications

SCF
Polyclonal
Unconjugated
KITLG
710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; Hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; Slf; Soluble KIT ligand; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Rabbit
Protein A
RUO
4254
-20°C
Liquid
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P21583
KITLG
KLH conjugated synthetic peptide derived from human SCF.
100 μL
Primary
Human
Antibody
IgG
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