Invitrogen™ SCG5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553020

Catalog No. PIPA553020

Description

Immunogen sequence: EGLQHLGPFG NIPNIVAELT GDNIPKDFSE DQGYPDPPNP CPVGKTADDG CLENTPDTAE FSREFQLHQH LFDPEHDYPG LGKWNKKLLY EKMKGGERRK RRSVNPYLQG QRLDNVVAKK SV Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Specifications

• Antigen: SCG5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scg5
• Gene Alias: 7B2; AI325031; C-terminal peptide; hypothetical protein MGC73132; LOC508224 protein; Neuroendocrine protein 7B2; neuronal endocrine protein; N-terminal peptide; P SGNE1; P7B2; pituitary polypeptide; prohormone convertase chaperone; SCG5; Secretogranin V; secretogranin V (7B2 protein); secretogranin-5; Secretory granule endocrine protein I; secretory granule neuroendocrine protein 1; secretory granule neuroendocrine protein 1, 7B2 protein; Secretory granule neuroendocrine, protein 1 (7B2 protein); secretory granule, neuroendocrine protein 1; secretory granule, neuroendocrine protein 1 (7B2 protein); SGNE1; Sgne-1; SgV; zgc:73132
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6447
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P05408
• Gene Symbols: Scg5
• Immunogen: Recombinant protein corresponding to Human SCG5. Recombinant protein control fragment (Product #RP-89933).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG